mobi ✓ Bottle of Lies The Inside Story of the Generic Drug Boom ebook ß gwairsoft

Katherine Eban í Bottle of Lies The Inside Story of the Generic Drug Boom pdf

mobi ✓ Bottle of Lies The Inside Story of the Generic Drug Boom ebook ß gwairsoft ß ➿ [Download] ➽ Bottle of Lies The Inside Story of the Generic Drug Boom By Katherine Eban ➵ – Katherine Eban’s Bottle of Lies exposes the deceit behind geneAran Africa and Brazil and represents the ultimate litmus test of globalization what are the risks of moving drug manufacturing offshore and are they worth the savings A decade long investigation with international sweep high stakes brinkmanship and big money at its core Bottle of Lies reveals how the world’s greatest public health innovation has become one of its most astonishing swindles  We all need to thank Katherine Eban for her phenomenal book Bottle of Lies This is a must read book especially if you're taking generic drugs I spent a lot of time after reading Eban's book researching the companies who make the generic drugs I take I am definitely switching away from certain generics based on my reading of Bottle of Lies Eban's Bottle of Lies is a blockbuster and needs to be on every 2019 Best Of list My gratitude for the courage of people who spoke up and who were whistle blowers Eban covers their stories expertly Just wow 📕💊

epub ´ Bottle of Lies The Inside Story of the Generic Drug Boom í Katherine Eban

Katherine Lies The Inside Story PDF Eban’s Lies The Kindle #213 Bottle of Lies exposes the deceit behind generic drug manufacturing and the attendant risks for global health Drawing on exclusive accounts Bottle of PDFEPUB or from whistleblowers and regulators as well as thousands of pages of confidential FDA documents Eban reveals an industry where fraud is rampant companies of Lies The eBook Before now I had a pretty rosy view of generic drugs I assumed they were chemically identical to the brand name drugs minus the exorbitant fees of the big pharmaceutical companies I also assumed there was an air tight system of checks in place to ensure their safety and efficacy In Katherine Eban's Bottle of Lies The Inside Story of the Generic Drug Boom I learned the picture is far complicated than that Eban tells the story of Ranbaxy an Indian generic drug company and how it lied and cheated for years to create competitively priced generic drugs at minimal cost while endangering patients the world overEban describes the intricate trials and approvals a large pharmaceutical company goes through to create a drug Once it has produced an effective treatment it has two decades to corner the market and rake in record profits After that the patent expires and generic companies fight to be the first to get approval from the FDA to produce their own version for an exclusive six month period before the market is open to everyone else To do this they must first figure out how to reverse engineer the drug being careful to avoid certain procedural steps the original producer still holds patents on and run tests for efficacy ingredient release time window and so forth within certain acceptable parameters Then they present a credible proposal to the FDA showing they can ramp up production and make the drug available in sufficient and affordable ualitiesRanbaxy was one of those generics companies known for being particularly adept at reverse engineering drugs They would send their representatives to wait overnight in the FDA parking lot in an attempt to get their proposals in first everyone did this until the FDA stopped enforcing a first come first served rule Their first big claim to fame was when they began producing AIDS drugs at cut rate prices that could make life saving treatments available to people in all countries; not just the rich ones This won Ranbaxy face time with and praise from former president Bill Clinton and put them on the map as one of the top generics contenders They secured the rights to dozens of other drugs as wellEban makes it clear that Ranbaxy had the technical know how to create effective drugs that wasn't the problem The problem was that in order to cut costs and maximize profits they would systematically fake results introduce impurities change suppliers hire illiterate and untrained workers mix in cheaper or failed batches of ingredients and generally flout all the FDA guidelines they'd agreed to This reuired lying about failed tests copying results from good batches and applying them to bad ones aping results from the actual brand name drugs altering or destroying records running non networked testing machines misleading inspectors and of course threatening whistleblowersTo complicate matters Ranbaxy would vary its products based on markets so that countries with strict uality oversight such as the US got the best versions of a product while a poor country got a mixture so degraded as to be useless or even harmful When confronted about the useless batches of AIDS drugs being sent to Africa a top medical executive at Ranbaxy said Who cares It's just blacks dying Beyond being horribly unethical this was obviously a practice that would be noticed at some point Doctors began realizing that when dealing with low grade generics they'd have to multiply dosages to get the same effects or sometimes find their patients worse off If they switched a patient to the far expensive brand name drugs they would see an immediate turnaround and improvement a testament to the uality of the drug that was termed the Lazarus effect At one point inspectors found drug batches with visible black particles In another instance small shards of blue glass were found in Ranbaxy pills While Ranbaxy is the primary target of this book other companies did this too When Israeli company Teva began making a generic version of Wellbutrin XL many patients found themselves sick sleep deprived irritable and even suicidalThese red flags would occasionally prompt the FDA to demand fresh reporting from Ranbaxy which set off an immediate panicked effort to throw them off and conjure faked results Some employees such as Raj Kumar and Dinesh Thakur caught on to what was happening and demanded that the company start behaving ethically Both were shocked to find out that the directors knew about this behavior They both uit out of frustration but Thakur began a silent many year campaign to feed the FDA what he knew This whistleblowing effort combined with the careful work and surprise inspections of star investigators like Peter Baker led to the full story of Ranbaxy's mendacity coming to light and a massive 500 million judgment against the companyThe bulk of the book expands on how the take down happened the evasions intimidations disgusting conditions legal standoffs delays and sometimes stupefying laziness and complacency involved on both sides Some of it is jawdropping and some of it is exhausting and repetitive I guarantee you'll never find a book that uses the word Ranbaxy this much Still it's an important story and I'm glad this exposé will serve as an example of why it doesn't pay to cheat At the same time Eban reminds us that the cat and mouse game never stops and that our faith in the products should only be as good as the oversight structure we have in place There couldn't be a better example of why regulation is so important In the meantime be ready to study up a bit before you assume a generic drug is identical to the originalFollowing up with a helpful link I learned about in our book club meeting Katherine Eban shares a helpful guide on how to research the safety of generic drugs on her site

doc Bottle of Lies The Inside Story of the Generic Drug Boom

Bottle of Lies The Inside Story of the Generic Drug Boom#180 routinely falsify data and executives circumvent almost every principle of safe manufacturing to minimize cost and maximize profit confident in their ability to of Lies The Inside Story Kindle fool inspectors Meanwhile patients unwittingly consume medicine with unpredictable and dangerous effectsThe story of generic drugs is truly global It connects middle America to China India sub Sah After a long time I read a book that was captivating and enthralling right till the end Katherine Eban has done full justice to her years of painstaking research on the pharma industry This book has brought to light the various malpractices the pharma industry indulges in to pass the muster in FDA books and the key to US markets The book highlights the lax drug controls in developing countries like India and China to manufacture generic versions of branded expensive drugs It has detailed how Ranbaxy flouted good manufacturing practices and permeated a system of corruption and record manipulation in their company It took a whistleblower like Dinesh Thakur to bring out the malpractices to the attention of FDA To compound his problems including living in constant fear for his family the FDA also took its own time around eight years to finally take action against Ranbaxy This was only because of a few officials' dogged persistence to pursue justice The FDA is also not spared with uestionable practices high pressure lobbying by the US govt in cahoots with the drug industry and corrupt officials walking its corridorsThis book brings out the fact that poor inferior uality drugs are pushed to African Eastern European and South American countries where the drug controls are lax and corruption is widespread Kudos to the author this book definitely is an eye opener and a mindblowing read